Rollover Study for Continued Safety and Tolerability in Subjects Treated With Spartalizumab Alone or in Combination With Other Study Treatments

An Open-label, Multi-center Rollover Protocol for Continued Characterization of Safety and Tolerability for Subjects Who Have Participated in a Novartis-sponsored Spartalizumab Study as Single Agent or in Combination With Other Study Treatments

ClinicalTrials.gov Identifier: NCT04058756

Novartis Reference Number: CPDR001X2X01B

Last Update: Feb 16, 2023

See if you pre-qualify

All compounds are either investigational or being studied for (a) new use(s). Efficacy and safety have not been established. There is no guarantee that they will become commercially available for the use(s) under investigation. 

Study Description

The purpose of this study is to continue to assess safety and tolerability, and to allow continued access to study treatment for subjects already receiving spartalizumab as single agent or in combination with other study treatments.

Condition 
Advanced Solid Tumors
Phase 
Phase 1
Overall status 
Recruiting
Start date 
Oct 31, 2019
Completion date 
Mar 07, 2030
Gender 
All
Age(s)
18 Years and older (Adult, Older Adult)

Interventions

Drug
PDR001
PDR001

Eligibility Criteria

Inclusion Criteria:

Subject is currently enrolled in a pre-defined Novartis-sponsored study and is receiving spartalizumab as single agent or in combination with other study treatment,
Subject is currently deriving clinical benefit from the study treatment, as determined by the investigator.

Other protocol defined inclusion criteria may apply

Exclusion Criteria:

Subject has been permanently discontinued from spartalizumab in the parent protocol for any reason other than enrollment in the Roll over Study
Subject does not meet the criteria specified in the parent protocol criteria for continued study treatment.

Study Locations

United States
Columbia University Medical Center- New York Presbyterian
Recruiting
New York, 10032 - New York
Contact: Catherine Shu
United States
Providence Portland Medical Center
Recruiting
Portland, 97123 - Oregon
Contact: Ashley Drokin (503-215-6805) - [email protected] - Rom Leidner
United States
MD Anderson Cancer Center/University of Texas MDACC
Recruiting
Houston, 77030 - Texas
Contact: Funda Meric-Bernstam
United States
Belgium
Novartis Investigative Site
Recruiting
Leuven, 3000
-
Belgium
Novartis Investigative Site
Recruiting
Liege, 4000
-
Belgium
Canada
Novartis Investigative Site
Recruiting
Toronto, M5G 2M9
Ontario
Canada
Novartis Investigative Site
Recruiting
Montreal, H3T 1E2
Quebec
Canada
China
Novartis Investigative Site
Recruiting
Guangzhou, 510515
Guangdong
China
Novartis Investigative Site
Recruiting
Guangzhou, 510060
-
China
Czech Republic
Novartis Investigative Site
Recruiting
Brno, 656 53
Czech Republic
Czech Republic
France
Novartis Investigative Site
Recruiting
Villejuif Cedex, 94800
Villejuif
France
Novartis Investigative Site
Recruiting
Lyon Cedex, 69373
-
France
Novartis Investigative Site
Recruiting
Marseille Cedex 05, 13885
-
France
Germany
Novartis Investigative Site
Recruiting
Essen, 45147
-
Germany
Novartis Investigative Site
Recruiting
Heidelberg, 69120
-
Germany
Novartis Investigative Site
Recruiting
Jena, 07740
-
Germany
Novartis Investigative Site
Recruiting
Ulm, 89081
-
Germany
Hong Kong
Novartis Investigative Site
Recruiting
Hong Kong,
-
Hong Kong
Novartis Investigative Site
Recruiting
Shatin, New Territories,
-
Hong Kong
Italy
Novartis Investigative Site
Recruiting
Milano, 20132
MI
Italy
Novartis Investigative Site
Recruiting
Milano, 20133
MI
Italy
Novartis Investigative Site
Recruiting
Milano, 20141
MI
Italy
Novartis Investigative Site
Recruiting
Rozzano, 20089
MI
Italy
Novartis Investigative Site
Recruiting
Aviano, 33081
PN
Italy
Novartis Investigative Site
Recruiting
Napoli, 80131
-
Italy
Korea, Republic of
Novartis Investigative Site
Recruiting
Seoul, 03080
-
Korea, Republic of
Novartis Investigative Site
Recruiting
Seoul, 05505
-
Korea, Republic of
Netherlands
Novartis Investigative Site
Recruiting
Leiden, 2333 ZA
-
Netherlands
Spain
Novartis Investigative Site
Recruiting
Barcelona, 08035
Catalunya
Spain
Novartis Investigative Site
Recruiting
Valencia, 46010
Comunidad Valenciana
Spain
Novartis Investigative Site
Recruiting
Madrid, 28009
-
Spain
Novartis Investigative Site
Recruiting
Madrid, 28034
-
Spain
Novartis Investigative Site
Recruiting
Madrid, 28041
-
Spain
Switzerland
Novartis Investigative Site
Recruiting
Zuerich, 8091
-
Switzerland
Taiwan
Novartis Investigative Site
Recruiting
Taipei, 10041
-
Taiwan

Contacts

Name: 
Novartis Pharmaceuticals
Phone: 
Name: 
Novartis Pharmaceuticals
Phone: 

Have a question?

Call 1-888-669-6682 or email [email protected]