Alpelisib Plus Olaparib in Platinum-resistant/Refractory, High-grade Serous Ovarian Cancer, With no Germline BRCA Mutation Detected

EPIK-O: A Phase III, Multi-center, Randomized (1:1), Open-label, Active-controlled, Study to Assess the Efficacy and Safety of Alpelisib (BYL719) in Combination With Olaparib as Compared to Single Agent Cytotoxic Chemotherapy, in Participants With no Germline BRCA Mutation Detected, Platinum-resistant or Refractory, High-grade Serous Ovarian Cancer

ClinicalTrials.gov Identifier: NCT04729387

Novartis Reference Number: CBYL719K12301

Last Update: May 03, 2022

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All compounds are either investigational or being studied for (a) new use(s). Efficacy and safety have not been established. There is no guarantee that they will become commercially available for the use(s) under investigation. 

Study Description

The objective of this study is to assess the efficacy and safety of the combination of alpelisib and olaparib compared with single agent cytotoxic chemotherapy in patients with platinum resistant or refractory high-grade serous ovarian cancer, with no germline BRCA mutation detected.

Condition 
Ovarian Cancer
Phase 
Phase 3
Overall status 
Recruiting
Start date 
Jul 02, 2021
Completion date 
Jan 31, 2025
Gender 
All
Age(s)
18 Years and older (Adult, Older Adult)

Interventions

Drug
Alpelisib
Alpelisib will be administered at 200 mg orally once daily following food on a continuous dosing schedule starting on Cycle 1 Day 1 in a 28-day cycle
Drug
Olaparib
Olaparib will be administered at 200 mg orally twice daily irrespective of meals on a continuous dosing schedule starting on Cycle 1 Day 1 in a 28-day cycle.
Drug
Paclitaxel
Paclitaxel will be administered at 80 mg/m2 as an intravenous infusion weekly during a 28-day treatment cycle, starting on Cycle 1 Day 1, and on Day 8, Day 15 and Day 22 of every cycle thereafter
Drug
Pegylated liposomal doxorubicin (PLD)
PLD will be administered at 40-50 mg/m2 (physician discretion) as an intravenous infusion once every 28-days in a 28 day treatment cycle, starting on Cycle 1 Day 1
Drug
Alpelisib
Alpelisib will be administered at 200 mg orally once daily following food on a continuous dosing schedule starting on Cycle 1 Day 1 in a 28-day cycle
Drug
Olaparib
Olaparib will be administered at 200 mg orally twice daily irrespective of meals on a continuous dosing schedule starting on Cycle 1 Day 1 in a 28-day cycle.
Drug
Paclitaxel
Paclitaxel will be administered at 80 mg/m2 as an intravenous infusion weekly during a 28-day treatment cycle, starting on Cycle 1 Day 1, and on Day 8, Day 15 and Day 22 of every cycle thereafter
Drug
Pegylated liposomal doxorubicin (PLD)
PLD will be administered at 40-50 mg/m2 (physician discretion) as an intravenous infusion once every 28-days in a 28 day treatment cycle, starting on Cycle 1 Day 1
Drug
Alpelisib
Alpelisib will be administered at 200 mg orally once daily following food on a continuous dosing schedule starting on Cycle 1 Day 1 in a 28-day cycle
Drug
Olaparib
Olaparib will be administered at 200 mg orally twice daily irrespective of meals on a continuous dosing schedule starting on Cycle 1 Day 1 in a 28-day cycle.
Drug
Paclitaxel
Paclitaxel will be administered at 80 mg/m2 as an intravenous infusion weekly during a 28-day treatment cycle, starting on Cycle 1 Day 1, and on Day 8, Day 15 and Day 22 of every cycle thereafter
Drug
Pegylated liposomal doxorubicin (PLD)
PLD will be administered at 40-50 mg/m2 (physician discretion) as an intravenous infusion once every 28-days in a 28 day treatment cycle, starting on Cycle 1 Day 1
Drug
Alpelisib
Alpelisib will be administered at 200 mg orally once daily following food on a continuous dosing schedule starting on Cycle 1 Day 1 in a 28-day cycle
Drug
Olaparib
Olaparib will be administered at 200 mg orally twice daily irrespective of meals on a continuous dosing schedule starting on Cycle 1 Day 1 in a 28-day cycle.
Drug
Paclitaxel
Paclitaxel will be administered at 80 mg/m2 as an intravenous infusion weekly during a 28-day treatment cycle, starting on Cycle 1 Day 1, and on Day 8, Day 15 and Day 22 of every cycle thereafter
Drug
Pegylated liposomal doxorubicin (PLD)
PLD will be administered at 40-50 mg/m2 (physician discretion) as an intravenous infusion once every 28-days in a 28 day treatment cycle, starting on Cycle 1 Day 1

Eligibility Criteria

Inclusion Criteria:

Participant has histologically confirmed diagnosis of high-grade serous or high-grade endometrioid ovarian cancer, fallopian tube cancer, or primary peritoneal cancer
Measurable disease, i.e., at least one measurable lesion per RECIST 1.1 criteria (a lesion at a previously irradiated site may only be counted as a target lesion if there is clear sign of progression since the irradiation)
If no measurable disease is present, the disease should be assessable by Gynecologic Cancer Intergroup criteria (GCIC) for CA-125
Participant has no germline BRCA1/2 mutation as determined by an FDA approved assay.
Participant has an Eastern Cooperative Oncology Group (ECOG) performance status of 0 or 1
Participant has platinum-resistant (progression within one to six months after completing platinum-based therapy) or platinum refractory disease (progression during treatment or within 4 weeks after the last dose), where platinum-based therapy is not an option, according to the GCIG 5th Ovarian Cancer Consensus Conference definitions. The platinum-based chemotherapy regimen does not necessarily need to be the last regimen the participant received prior to study entry.
Participant must have received at least one but no more than three prior systemic treatment regimens and for whom single-agent chemotherapy is appropriate as the next line of treatment.
Participant has adequate bone marrow and organ function

Exclusion Criteria:

Participant has received prior treatment with any PI3K, mTOR or AKT inhibitor.
Participant is concurrently using other anti-cancer therapy
Participant is in a state of small or large bowel obstruction or has other impairment of gastrointestinal (GI) function or GI disease
Participant has had surgery within 14 days prior to starting study drug or has not recovered from major side effects
Participant has not recovered from all toxicities 5 related to prior anticancer therapies to baseline or NCI CTCAE Version 4.03 Grade ≤1. Exception to this criterion: participants with any grade of alopecia are allowed to enter the study.
Participants with liver impairment and Child Pugh score B or C
Participant has received radiotherapy ≤ 4 weeks or limited field radiation for palliation ≤2 weeks prior to randomization, and who has not recovered to baseline, grade 1 or better from related side effects of such therapy (with the exception of alopecia).
Participant has a known hypersensitivity to any of the study drugs or excipients

Other inclusion/exclusion criteria may apply

Study Locations

United States
US Oncology
Recruiting
Phoenix, 85016 - Arizona
Contact: Theresa Thomas (602-253-5300) - [email protected] - Bradley Monk
United States
Arizona Oncology Associates SC
Recruiting
Phoenix, 85710 - Arizona
Contact: Crystal Mata (520-886-0206) - [email protected] - Joseph Buscema
United States
Highlands Oncology Group Main
Recruiting
Fayetteville, 72703 - Arkansas
Contact: Heather Campbell (479-872-8130) - [email protected] - J. Thaddeus Beck
United States
Florida Cancer Specialists Dept of Oncology (2)
Recruiting
Fort Myers, 33901 - Florida
Contact: Lyrae Layne (727-216-1143) - [email protected] - Jennifer L Cultrera
United States
Florida Cancer Specialists
Recruiting
Fort Myers, 33901 - Florida
Contact: Lukas Escobar (239-274-9930) - [email protected] - Elizabeth Guancial
United States
Florida Cancer Specialists Panhandle
Recruiting
Tallahassee, 32308 - Florida
Contact: Sheila Gagne (615-329-7482) - [email protected] - Margarett Ellison
United States
Florida Cancer Specialists
Recruiting
West Palm Beach, 33401 - Florida
Contact: Gabrielle Jasmin (561-366-4149) - [email protected] - Todd Gersten
United States
Illinois Cancer Specialists
Recruiting
Arlington Heights, 60005 - Illinois
Contact: (847-259-4482) Urszula Sobol
United States
Maryland Oncology Hematology P A
Recruiting
Silver Spring, 20904 - Maryland
Contact: Jennifer Cipriano (999-999-9999) - [email protected] - Frederick Min
United States
Dana Farber Cancer Institute
Recruiting
Boston, 02115 - Massachusetts
Contact: Eliana Ellenberger (617-632-5136) - [email protected] - Panagiotis Konstantinopoulos
United States
Memorial Sloan Kettering Cancer Center
Recruiting
New York, 10065 - New York
Contact: Gina Piekarski - [email protected] - Rachel Grisham
United States
Oncology Hematology Care Inc
Recruiting
Cincinnati, 45242 - Ohio
Contact: Alessandra Hubbell - [email protected] - Cynthia Coo Chua
United States
University of Cincinnati Dept of Oncology
Recruiting
Cincinnati, 45267 - Ohio
Contact: Ashley Ballman (513-584-0429) - [email protected] - Thomas Herzog
United States
Avera Cancer Institute
Recruiting
Sioux Falls, 57106 - South Dakota
Contact: Natasha Flier (605-322-3000) - [email protected] - David Starks
United States
Sarah Cannon Research Institute
Recruiting
Nashville, 37203 - Tennessee
Contact: Jeremy Gilbert (+1 615 340 1515) - [email protected] - Erika Paige Hamilton
United States
Texas Oncology, P.A. Texas Oncology - South Austin
Recruiting
Bedford, 76022 - Texas
Contact: Francisca Fernandez (512-912-2761) - [email protected] - Michael Teneriello
United States
Texas Oncology Charles A. Sammons Cancer Ctr
Recruiting
Dallas, 75246 - Texas
Contact: Melissa Clark - [email protected] - Carolyn Matthews
United States
Texas Oncology P A
Recruiting
San Antonio, 78217 - Texas
Contact: Debbie A Ponce - [email protected] - Antonio Santillan-Gomez
United States
US Oncology P A
Recruiting
Tyler, 75702 - Texas
Contact: Shelly Maxfield (903-579-9800) - [email protected] - Anna Priebe
United States
US Oncology
Recruiting
Phoenix, 85016 - Arizona
Contact: Theresa Thomas (602-253-5300) - [email protected] - Bradley Monk
United States
Arizona Oncology Associates SC
Recruiting
Phoenix, 85710 - Arizona
Contact: Crystal Mata (520-886-0206) - [email protected] - Joseph Buscema
United States
Highlands Oncology Group Main
Recruiting
Fayetteville, 72703 - Arkansas
Contact: Heather Campbell (479-872-8130) - [email protected] - J. Thaddeus Beck
United States
Florida Cancer Specialists Dept of Oncology (2)
Recruiting
Fort Myers, 33901 - Florida
Contact: Lyrae Layne (727-216-1143) - [email protected] - Jennifer L Cultrera
United States
Florida Cancer Specialists
Recruiting
Fort Myers, 33901 - Florida
Contact: Lukas Escobar (239-274-9930) - [email protected] - Elizabeth Guancial
United States
Florida Cancer Specialists Panhandle
Recruiting
Tallahassee, 32308 - Florida
Contact: Sheila Gagne (615-329-7482) - [email protected] - Margarett Ellison
United States
Florida Cancer Specialists
Recruiting
West Palm Beach, 33401 - Florida
Contact: Gabrielle Jasmin (561-366-4149) - [email protected] - Todd Gersten
United States
Illinois Cancer Specialists
Recruiting
Arlington Heights, 60005 - Illinois
Contact: (847-259-4482) Urszula Sobol
United States
Maryland Oncology Hematology P A
Recruiting
Silver Spring, 20904 - Maryland
Contact: Jennifer Cipriano (999-999-9999) - [email protected] - Frederick Min
United States
Dana Farber Cancer Institute
Recruiting
Boston, 02115 - Massachusetts
Contact: Eliana Ellenberger (617-632-5136) - [email protected] - Panagiotis Konstantinopoulos
United States
Memorial Sloan Kettering Cancer Center
Recruiting
New York, 10065 - New York
Contact: Gina Piekarski - [email protected] - Rachel Grisham
United States
Oncology Hematology Care Inc
Recruiting
Cincinnati, 45242 - Ohio
Contact: Alessandra Hubbell - [email protected] - Cynthia Coo Chua
United States
University of Cincinnati Dept of Oncology
Recruiting
Cincinnati, 45267 - Ohio
Contact: Ashley Ballman (513-584-0429) - [email protected] - Thomas Herzog
United States
Avera Cancer Institute
Recruiting
Sioux Falls, 57106 - South Dakota
Contact: Natasha Flier (605-322-3000) - [email protected] - David Starks
United States
Sarah Cannon Research Institute
Recruiting
Nashville, 37203 - Tennessee
Contact: Jeremy Gilbert (+1 615 340 1515) - [email protected] - Erika Paige Hamilton
United States
Texas Oncology, P.A. Texas Oncology - South Austin
Recruiting
Bedford, 76022 - Texas
Contact: Francisca Fernandez (512-912-2761) - [email protected] - Michael Teneriello
United States
Texas Oncology Charles A. Sammons Cancer Ctr
Recruiting
Dallas, 75246 - Texas
Contact: Melissa Clark - [email protected] - Carolyn Matthews
United States
Texas Oncology P A
Recruiting
San Antonio, 78217 - Texas
Contact: Debbie A Ponce - [email protected] - Antonio Santillan-Gomez
United States
US Oncology P A
Recruiting
Tyler, 75702 - Texas
Contact: Shelly Maxfield (903-579-9800) - [email protected] - Anna Priebe
United States
US Oncology
Recruiting
Phoenix, 85016 - Arizona
Contact: Theresa Thomas (602-253-5300) - [email protected] - Bradley Monk
United States
Arizona Oncology Associates SC
Recruiting
Phoenix, 85710 - Arizona
Contact: Crystal Mata (520-886-0206) - [email protected] - Joseph Buscema
United States
Highlands Oncology Group Main
Recruiting
Fayetteville, 72703 - Arkansas
Contact: Heather Campbell (479-872-8130) - [email protected] - J. Thaddeus Beck
United States
Florida Cancer Specialists Dept of Oncology (2)
Recruiting
Fort Myers, 33901 - Florida
Contact: Lyrae Layne (727-216-1143) - [email protected] - Jennifer L Cultrera
United States
Florida Cancer Specialists
Recruiting
Fort Myers, 33901 - Florida
Contact: Lukas Escobar (239-274-9930) - [email protected] - Elizabeth Guancial
United States
Florida Cancer Specialists Panhandle
Recruiting
Tallahassee, 32308 - Florida
Contact: Sheila Gagne (615-329-7482) - [email protected] - Margarett Ellison
United States
Florida Cancer Specialists
Recruiting
West Palm Beach, 33401 - Florida
Contact: Gabrielle Jasmin (561-366-4149) - [email protected] - Todd Gersten
United States
Illinois Cancer Specialists
Recruiting
Arlington Heights, 60005 - Illinois
Contact: (847-259-4482) Urszula Sobol
United States
Maryland Oncology Hematology P A
Recruiting
Silver Spring, 20904 - Maryland
Contact: Jennifer Cipriano (999-999-9999) - [email protected] - Frederick Min
United States
Dana Farber Cancer Institute
Recruiting
Boston, 02115 - Massachusetts
Contact: Eliana Ellenberger (617-632-5136) - [email protected] - Panagiotis Konstantinopoulos
United States
Memorial Sloan Kettering Cancer Center
Recruiting
New York, 10065 - New York
Contact: Gina Piekarski - [email protected] - Rachel Grisham
United States
Oncology Hematology Care Inc
Recruiting
Cincinnati, 45242 - Ohio
Contact: Alessandra Hubbell - [email protected] - Cynthia Coo Chua
United States
University of Cincinnati Dept of Oncology
Recruiting
Cincinnati, 45267 - Ohio
Contact: Ashley Ballman (513-584-0429) - [email protected] - Thomas Herzog
United States
Avera Cancer Institute
Recruiting
Sioux Falls, 57106 - South Dakota
Contact: Natasha Flier (605-322-3000) - [email protected] - David Starks
United States
Sarah Cannon Research Institute
Recruiting
Nashville, 37203 - Tennessee
Contact: Jeremy Gilbert (+1 615 340 1515) - [email protected] - Erika Paige Hamilton
United States
Texas Oncology, P.A. Texas Oncology - South Austin
Recruiting
Bedford, 76022 - Texas
Contact: Francisca Fernandez (512-912-2761) - [email protected] - Michael Teneriello
United States
Texas Oncology Charles A. Sammons Cancer Ctr
Recruiting
Dallas, 75246 - Texas
Contact: Melissa Clark - [email protected] - Carolyn Matthews
United States
Texas Oncology P A
Recruiting
San Antonio, 78217 - Texas
Contact: Debbie A Ponce - [email protected] - Antonio Santillan-Gomez
United States
US Oncology P A
Recruiting
Tyler, 75702 - Texas
Contact: Shelly Maxfield (903-579-9800) - [email protected] - Anna Priebe
United States
US Oncology
Recruiting
Phoenix, 85016 - Arizona
Contact: Theresa Thomas (602-253-5300) - [email protected] - Bradley Monk
United States
Arizona Oncology Associates SC
Recruiting
Phoenix, 85710 - Arizona
Contact: Crystal Mata (520-886-0206) - [email protected] - Joseph Buscema
United States
Highlands Oncology Group Main
Recruiting
Fayetteville, 72703 - Arkansas
Contact: Heather Campbell (479-872-8130) - [email protected] - J. Thaddeus Beck
United States
Florida Cancer Specialists Dept of Oncology (2)
Recruiting
Fort Myers, 33901 - Florida
Contact: Lyrae Layne (727-216-1143) - [email protected] - Jennifer L Cultrera
United States
Florida Cancer Specialists
Recruiting
Fort Myers, 33901 - Florida
Contact: Lukas Escobar (239-274-9930) - [email protected] - Elizabeth Guancial
United States
Florida Cancer Specialists Panhandle
Recruiting
Tallahassee, 32308 - Florida
Contact: Sheila Gagne (615-329-7482) - [email protected] - Margarett Ellison
United States
Florida Cancer Specialists
Recruiting
West Palm Beach, 33401 - Florida
Contact: Gabrielle Jasmin (561-366-4149) - [email protected] - Todd Gersten
United States
Illinois Cancer Specialists
Recruiting
Arlington Heights, 60005 - Illinois
Contact: (847-259-4482) Urszula Sobol
United States
Maryland Oncology Hematology P A
Recruiting
Silver Spring, 20904 - Maryland
Contact: Jennifer Cipriano (999-999-9999) - [email protected] - Frederick Min
United States
Dana Farber Cancer Institute
Recruiting
Boston, 02115 - Massachusetts
Contact: Eliana Ellenberger (617-632-5136) - [email protected] - Panagiotis Konstantinopoulos
United States
Memorial Sloan Kettering Cancer Center
Recruiting
New York, 10065 - New York
Contact: Gina Piekarski - [email protected] - Rachel Grisham
United States
Oncology Hematology Care Inc
Recruiting
Cincinnati, 45242 - Ohio
Contact: Alessandra Hubbell - [email protected] - Cynthia Coo Chua
United States
University of Cincinnati Dept of Oncology
Recruiting
Cincinnati, 45267 - Ohio
Contact: Ashley Ballman (513-584-0429) - [email protected] - Thomas Herzog
United States
Avera Cancer Institute
Recruiting
Sioux Falls, 57106 - South Dakota
Contact: Natasha Flier (605-322-3000) - [email protected] - David Starks
United States
Sarah Cannon Research Institute
Recruiting
Nashville, 37203 - Tennessee
Contact: Jeremy Gilbert (+1 615 340 1515) - [email protected] - Erika Paige Hamilton
United States
Texas Oncology, P.A. Texas Oncology - South Austin
Recruiting
Bedford, 76022 - Texas
Contact: Francisca Fernandez (512-912-2761) - [email protected] - Michael Teneriello
United States
Texas Oncology Charles A. Sammons Cancer Ctr
Recruiting
Dallas, 75246 - Texas
Contact: Melissa Clark - [email protected] - Carolyn Matthews
United States
Texas Oncology P A
Recruiting
San Antonio, 78217 - Texas
Contact: Debbie A Ponce - [email protected] - Antonio Santillan-Gomez
United States
US Oncology P A
Recruiting
Tyler, 75702 - Texas
Contact: Shelly Maxfield (903-579-9800) - [email protected] - Anna Priebe
United States
Argentina
Novartis Investigative Site
Recruiting
Caba, C1125ABD
Buenos Aires
Argentina
Novartis Investigative Site
Recruiting
Caba, C1125ABD
Buenos Aires
Argentina
Novartis Investigative Site
Recruiting
Caba, C1125ABD
Buenos Aires
Argentina
Novartis Investigative Site
Recruiting
Caba, C1125ABD
Buenos Aires
Argentina
Australia
Novartis Investigative Site
Recruiting
Bedford Park, 5041
South Australia
Australia
Novartis Investigative Site
Recruiting
Shepparton, 3630
Victoria
Australia
Novartis Investigative Site
Recruiting
Bedford Park, 5041
South Australia
Australia
Novartis Investigative Site
Recruiting
Shepparton, 3630
Victoria
Australia
Novartis Investigative Site
Recruiting
Bedford Park, 5041
South Australia
Australia
Novartis Investigative Site
Recruiting
Shepparton, 3630
Victoria
Australia
Novartis Investigative Site
Recruiting
Bedford Park, 5041
South Australia
Australia
Novartis Investigative Site
Recruiting
Shepparton, 3630
Victoria
Australia
Austria
Novartis Investigative Site
Recruiting
Innsbruck, 6020
Tyrol
Austria
Novartis Investigative Site
Recruiting
Graz, 8036
-
Austria
Novartis Investigative Site
Recruiting
Innsbruck, 6020
Tyrol
Austria
Novartis Investigative Site
Recruiting
Graz, 8036
-
Austria
Novartis Investigative Site
Recruiting
Innsbruck, 6020
Tyrol
Austria
Novartis Investigative Site
Recruiting
Graz, 8036
-
Austria
Novartis Investigative Site
Recruiting
Innsbruck, 6020
Tyrol
Austria
Novartis Investigative Site
Recruiting
Graz, 8036
-
Austria
Belgium
Novartis Investigative Site
Recruiting
Bruxelles, 1000
-
Belgium
Novartis Investigative Site
Recruiting
Leuven, 3000
-
Belgium
Novartis Investigative Site
Recruiting
Namur, 5000
-
Belgium
Novartis Investigative Site
Recruiting
Bruxelles, 1000
-
Belgium
Novartis Investigative Site
Recruiting
Leuven, 3000
-
Belgium
Novartis Investigative Site
Recruiting
Namur, 5000
-
Belgium
Novartis Investigative Site
Recruiting
Bruxelles, 1000
-
Belgium
Novartis Investigative Site
Recruiting
Leuven, 3000
-
Belgium
Novartis Investigative Site
Recruiting
Namur, 5000
-
Belgium
Novartis Investigative Site
Recruiting
Bruxelles, 1000
-
Belgium
Novartis Investigative Site
Recruiting
Leuven, 3000
-
Belgium
Novartis Investigative Site
Recruiting
Namur, 5000
-
Belgium
Brazil
Novartis Investigative Site
Recruiting
Sao Paulo, 01317-002
SP
Brazil
Novartis Investigative Site
Recruiting
Sao Paulo, 03102-002
SP
Brazil
Novartis Investigative Site
Recruiting
Sao Paulo, 01317-002
SP
Brazil
Novartis Investigative Site
Recruiting
Sao Paulo, 03102-002
SP
Brazil
Novartis Investigative Site
Recruiting
Sao Paulo, 01317-002
SP
Brazil
Novartis Investigative Site
Recruiting
Sao Paulo, 03102-002
SP
Brazil
Novartis Investigative Site
Recruiting
Sao Paulo, 01317-002
SP
Brazil
Novartis Investigative Site
Recruiting
Sao Paulo, 03102-002
SP
Brazil
Canada
Novartis Investigative Site
Recruiting
Calgary, T2N 4N2
Alberta
Canada
Novartis Investigative Site
Recruiting
Vancouver, V5Z 4E6
British Columbia
Canada
Novartis Investigative Site
Recruiting
London, N6A 4L6
Ontario
Canada
Novartis Investigative Site
Recruiting
Toronto, M4N 3M5
Ontario
Canada
Novartis Investigative Site
Recruiting
Calgary, T2N 4N2
Alberta
Canada
Novartis Investigative Site
Recruiting
Vancouver, V5Z 4E6
British Columbia
Canada
Novartis Investigative Site
Recruiting
London, N6A 4L6
Ontario
Canada
Novartis Investigative Site
Recruiting
Toronto, M4N 3M5
Ontario
Canada
Novartis Investigative Site
Recruiting
Calgary, T2N 4N2
Alberta
Canada
Novartis Investigative Site
Recruiting
Vancouver, V5Z 4E6
British Columbia
Canada
Novartis Investigative Site
Recruiting
London, N6A 4L6
Ontario
Canada
Novartis Investigative Site
Recruiting
Toronto, M4N 3M5
Ontario
Canada
Novartis Investigative Site
Recruiting
Calgary, T2N 4N2
Alberta
Canada
Novartis Investigative Site
Recruiting
Vancouver, V5Z 4E6
British Columbia
Canada
Novartis Investigative Site
Recruiting
London, N6A 4L6
Ontario
Canada
Novartis Investigative Site
Recruiting
Toronto, M4N 3M5
Ontario
Canada
China
Novartis Investigative Site
Recruiting
Beijing, 100036
-
China
Novartis Investigative Site
Recruiting
Jinan, 250012
-
China
Novartis Investigative Site
Recruiting
Shanghai, 200032
-
China
Novartis Investigative Site
Recruiting
Wuhan, 430022
-
China
Novartis Investigative Site
Recruiting
Beijing, 100036
-
China
Novartis Investigative Site
Recruiting
Jinan, 250012
-
China
Novartis Investigative Site
Recruiting
Shanghai, 200032
-
China
Novartis Investigative Site
Recruiting
Wuhan, 430022
-
China
Novartis Investigative Site
Recruiting
Beijing, 100036
-
China
Novartis Investigative Site
Recruiting
Jinan, 250012
-
China
Novartis Investigative Site
Recruiting
Shanghai, 200032
-
China
Novartis Investigative Site
Recruiting
Wuhan, 430022
-
China
Novartis Investigative Site
Recruiting
Beijing, 100036
-
China
Novartis Investigative Site
Recruiting
Jinan, 250012
-
China
Novartis Investigative Site
Recruiting
Shanghai, 200032
-
China
Novartis Investigative Site
Recruiting
Wuhan, 430022
-
China
Czech Republic
Novartis Investigative Site
Recruiting
Novy Jicin, 74101
Czech Republic
Czech Republic
Novartis Investigative Site
Recruiting
Brno, 62500
-
Czech Republic
Novartis Investigative Site
Recruiting
Ostrava Poruba, 708 52
-
Czech Republic
Novartis Investigative Site
Recruiting
Praha 2, 128 51
-
Czech Republic
Novartis Investigative Site
Recruiting
Novy Jicin, 74101
Czech Republic
Czech Republic
Novartis Investigative Site
Recruiting
Brno, 62500
-
Czech Republic
Novartis Investigative Site
Recruiting
Ostrava Poruba, 708 52
-
Czech Republic
Novartis Investigative Site
Recruiting
Praha 2, 128 51
-
Czech Republic
Novartis Investigative Site
Recruiting
Novy Jicin, 74101
Czech Republic
Czech Republic
Novartis Investigative Site
Recruiting
Brno, 62500
-
Czech Republic
Novartis Investigative Site
Recruiting
Ostrava Poruba, 708 52
-
Czech Republic
Novartis Investigative Site
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Herlev,
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Denmark
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Odense C, DK 5000
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Denmark
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Herlev,
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Denmark
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Odense C, DK 5000
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Denmark
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Herlev,
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Denmark
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Herlev,
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Denmark
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Odense C, DK 5000
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France
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France
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France
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Pierre Benite Cedex, 69495
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France
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France
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France
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Paris, 75012
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France
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Pierre Benite Cedex, 69495
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France
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France
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Besancon cedex, 25030
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France
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Paris, 75012
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France
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Seoul, 03722
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Seoul, 03080
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Seoul, 03722
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Seoul, 03080
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Singapore, 119228
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Singapore, 169610
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Singapore
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Singapore, 119228
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Singapore
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Singapore, 169610
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Singapore, 119228
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Bratislava, 83310
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Trencin, 91171
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Spain
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Cordoba, 14004
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Spain
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Barcelona, 08036
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Spain
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Comunidad Valenciana
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Navarra
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Spain
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Spain
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Barcelona, 08036
Catalunya
Spain
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Comunidad Valenciana
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Pamplona, 31008
Navarra
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Spain
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Barcelona, 08036
Catalunya
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Comunidad Valenciana
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Pamplona, 31008
Navarra
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Taichung, 40705
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Taipei, 10002
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Taichung, 40705
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Taipei, 10002
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Taiwan
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Taipei, 11217
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Taichung, 40705
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Turkey
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Adana, 01160
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Izmir,
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Trabzon, 61080
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Adana, 01160
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Izmir,
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Trabzon, 61080
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Adana, 01160
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Trabzon, 61080
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United Kingdom
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